SCIg Therapy on Your Terms - Octapharma® PI Treatment Options

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Primary Immunodeficiency Therapy on Your Terms

Cutaquig is used to treat adults and pediatric patients 2 years of age and older with primary immunodeficiency (PI) disease. There are many forms of PI. The most common types lead to an inability to make a very important kind of protein called antibodies, which protect your body against infections.¹ As a ready-to-use liquid solution containing immunoglobulin G—also known as IgG—cutaquig is made from human plasma donated by healthy people.^1,2 It contains the antibodies you may be missing.¹ Regular use of cutaquig will help your body to fight bacteria and viruses that cause infections.^1,2

Convenient

Cutaquig is a subcutaneous immunoglobulin therapy (or SCIg).¹ With SCIg, you infuse cutaquig under the skin instead of into a vein (infusing medication for PI into a vein is known as intravenous immunoglobulin therapy, or IVIg).¹ Once you’ve been trained by your healthcare provider, you’ll have the option to self-administer cutaquig.¹ Like most patients who choose to self-administer, you may gain a greater sense of freedom. Plus, cutaquig offers convenience—you may be able to self-administer almost anywhere, including home, work, or school.^3-5

Safe

Cutaquig offers proven safety.^1,5 The donated plasma from which it is made is rigorously tested to ensure purity and safety. With cutaquig therapy, there is a low rate of side effects—mostly local infusion site reactions, including but not limited to redness, swelling, and itching.^1,5 In a clinical study, most of the site reactions were mild or moderate.⁵

Effective

In clinical studies, adults and pediatric patients 2 years and older taking cutaquig had low overall rates of infection, with zero serious bacterial infections in a phase 3 clinical trial.^1,5,6 In addition, patients taking cutaquig experienced a low rate of absences from work or school due to infection.^1,6

Learn more about cutaquig SCIg replacement therapy

References

1. Cutaquig Full Prescribing Information. Paramus, NJ: Octapharma; rev October 2021.

2. Clinical Study Report SCGAM-01. Clinical Phase 3 study to evaluate the pharmacokinetics, efficacy, tolerability and safety of subcutaneous human immunoglobulin (octanorm 16.5%) in patients with primary immunodeficiency diseases. NCT01888484. June 2018. https://clinicaltrials.gov/ct2/show/NCT01888484. Accessed April 26, 2019.

3. McCormack PL. Immune globulin subcutaneous (human) 20% in primary immunodeficiency disorders. Drugs. 2012;72(8):1087-1097.

4. Kobrynski L. Subcutaneous immunoglobulin therapy: a new option for patients with primary immunodeficiency diseases. Biologics. 2012;6:277-287.

5. Kobayashi RH, Gupta S, Melamed I, et al. Clinical efficacy, safety and tolerability of a new subcutaneous immunoglobulin 16.5% (Octanorm [Cutaquig®]) in the treatment of patients with primary immunodeficiencies. Front Immunol. 2019;10(40):1-12.

6. Kobayashi RH, Mandujano JF, Rehman SM, et al. Treatment of children with primary immunodeficiencies with a subcutaneous immunoglobulin 16.5% (cutaquig® [octanorm]). Immunotherapy. 2021;13(10):813 -824.

Indications and Important Safety Information for cutaquig^® (Immune Globulin Subcutaneous [Human]– hipp, 16.5% solution)

WARNING: THROMBOSIS

See the cutaquig full prescribing information for complete boxed warning

Thrombosis may occur with immune globulin products, including cutaquig.

Indications and Important Safety Information for cutaquig^® (Immune Globulin Subcutaneous [Human]– hipp, 16.5% solution)

WARNING: THROMBOSIS

See the cutaquig full prescribing information for complete boxed warning

Thrombosis may occur with immune globulin products, including cutaquig.

Risk factors may include: advanced age, prolonged immobilization, hypercoagulable conditions, history of venous or arterial thrombosis, use of estrogens, indwelling vascular catheters, hyperviscosity, and cardiovascular risk factors.

For patients at risk of thrombosis, administer cutaquig at the minimum dose and infusion rate practicable. Ensure adequate hydration in patients before administration. Monitor for signs and symptoms of thrombosis and assess blood viscosity in patients at risk of hyperviscosity.

Indications and Usage

Cutaquig^® (Immune Globulin Subcutaneous (Human)-hipp) is a 16.5% immune globulin solution for subcutaneous infusion (IGSC), indicated as replacement therapy for primary humoral immunodeficiency (PI) in adults and pediatric patients 2 years of age and older. This includes, but is not limited to, common variable immunodeficiency (CVID), X-linked agammaglobulinemia, congenital agammaglobulinemia, Wiskott-Aldrich syndrome, and severe combined immunodeficiencies.

IMPORTANT SAFETY INFORMATION

Contraindications

Cutaquig is contraindicated in patients who have had an anaphylactic or severe systemic reaction to the subcutaneous administration of human immune globulin or to any of the components of cutaquig such as Polysorbate 80, and in IgA-deficient patients with antibodies against IgA and a history of hypersensitivity.

Warnings and Precautions

Severe hypersensitivity reactions may occur with cutaquig, even in patients who tolerated previous treatment with human immune globulin. If a hypersensitivity reaction occurs, discontinue the cutaquig infusion immediately and initiate appropriate treatment. IgA-deficient patients with anti-IgA antibodies are at greater risk of severe reactions.

Thrombosis may occur following treatment with immune globulin products, including cutaquig. For patients at risk of thrombosis, administer cutaquig at the minimum dose and infusion rate practicable. Ensure adequate hydration in patients before administration. Monitor for signs and symptoms of thrombosis and assess blood viscosity in patients at risk for hyperviscosity.

Falsely elevated blood glucose readings may occur during and after the infusion of cutaquig with some glucometer and test strip systems. When administering cutaquig, measure blood glucose with a glucose-specific method.

Aseptic meningitis syndrome (AMS) can occur with cutaquig. AMS has been reported after the use of human immune globulin administered intravenously and subcutaneously and may occur within 2 days following treatment. Discontinuation of immunoglobulin treatment has resulted in remission within several days without sequelae.

Acute renal dysfunction/failure, acute tubular necrosis, proximal tubular nephropathy, osmotic nephrosis and death may occur with use of human immune globulin, especially those containing sucrose. cutaquig does not contain sucrose. Monitor patients for signs and symptoms of renal dysfunction. Monitor blood urea nitrogen, serum creatinine, and urine output in patients at risk of acute renal failure.

Monitor cutaquig recipients for clinical signs and symptoms of hemolysis, particularly patients with pre-existing anemia and/or cardiovascular or pulmonary compromise. Consider appropriate confirmatory laboratory testing if signs and symptoms of hemolysis are present after cutaquig infusion.

Non-cardiogenic pulmonary edema may occur in patients administered human immune globulin products. Monitor for pulmonary adverse reactions (transfusion-related acute lung injury, TRALI). If TRALI is suspected, perform appropriate tests for the presence of anti-neutrophil antibodies in both the product and patient’s serum. Patients with TRALI may be managed using oxygen therapy with adequate ventilatory support.

Cutaquig is made from human plasma and may carry a risk of transmitting infectious agents, e.g. viruses, the variant Creutzfeldt-Jakob disease (vCJD) agent, and, theoretically, the Creutzfeldt-Jakob disease (CJD) agent.

Drug Interactions

After infusion of cutaquig, the transitory rise of the various passively transferred antibodies in the patient’s blood may yield false positive serological test results, with the potential for misleading interpretation.

Adverse Reactions

The most common adverse reactions (≥ 5% of study subjects) were local infusion site reactions (such as redness, swelling, itching), headache, fever, dermatitis, asthma, diarrhea, and cough.

Please see the cutaquig full prescribing information

CUTA-0624